Formulation And Evaluation of a Bilayer Mucoadhesive Buccal Drug Delivery System for Carvedilol Nanoparticles
Year: 2024
Type: article
Abstract: The main objective of this study was to formulate carvedilol nanoparticles into mucoadhesive bilayer tablets and evaluate the nanoparticle-loaded formulation. This approach aims to address the challenges of low solubility, poor bioavailability, and first-pass metabolism associated with carvedilol when administered in conventional oral dosage forms. Carvedilol nanoparticles were prepared using the nanoprecipitation method, as described in Ganesh R. Nayak et al. (Int. J. of Pharm. Sci., 2024, Vol. 2, Issue 7, 2010-2018). Bilayer buccal tablets were then prepared by direct compression and evaluated for their physicochemical properties. In vitro studies demonstrated that the carvedilol buccal tablet formulation containing nanoparticles could serve as a promising drug delivery system.
Author: Ganesh Nayak1*, Akshay Killekar2, Krishnananda Kamath K.1, A. R. Shabaraya1, Viresh Chandur1
Language: English
Subfield: Pharmaceutical Science
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W6967986616
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