Antioxidant and anti-inflammatory functions of turmeric and cucumber juice following lead-induced toxicity in male Wistar rats
Year: 2024
Type: article
Abstract: Reactive oxygen species and free radicals generated by oxidative stress and inflammation have been implicated in various clinical conditions. This study aimed to evaluate the antioxidant and anti-inflammatory effects of turmeric and cucumber juice following lead-induced toxicity in male Wistar rats. Twenty-five male rats (170–250 g) were randomly divided into five groups (n = 5 per group). Lead toxicity was induced in all rats by a single daily oral dose of 2.25 mg/kg, except in Group 1, which served as the control. The treatment was administered for 28 days as follows: Group 1 (control) received no treatment; Group 2 (Pb only) received 2.25 mg/kg of lead; Group 3 (Pb + TURM) received 2.25 mg/kg of lead with 1 ml of turmeric juice; Group 4 (Pb + CUM) received 2.25 mg/kg of lead with 1 ml of cucumber juice; and Group 5 (Pb + TURM + CUM) received 2.25 mg/kg of lead with 1 ml of both turmeric and cucumber juice. On day 29, blood samples were collected for serum analysis of antioxidants (malondialdehyde [MDA], superoxide dismutase [SOD], catalase [CAT]) and inflammatory markers (interleukin-6 [IL-6] and tumor necrosis factor-alpha [TNF-α]). Rats in Group 2 (Pb only) exhibited significantly higher levels of MDA, IL-6, and TNF-α, and lower levels of SOD and CAT compared to the control group (p < 0.05), indicating oxidative damage and inflammation. Treatment with turmeric and cucumber juice in Groups 3 and 4 significantly reduced MDA, IL-6, and TNF-α, and increased SOD and CAT levels (p < 0.05). Co-administration of both juices in Group 5 resulted in even more pronounced effects, suggesting a synergistic benefit. The mechanism of action remains under investigation.
Authors: F. Saronee, T. A. Kolawole, B. D. Amieye, N. G. Amadi, J. E. Amadi, R. B. Buduburisi, D. V. Dapper
Language: English
Subfield: Health, Toxicology and Mutagenesis
Field: Environmental Science
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W6968092121
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