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In Vitro Evaluation of Genotoxicity of a Commercial Polyaxial Pedicle Screw for Spine Surgery

Year: 2024

Type: article

Abstract: Biocompatibility, which shows the compatibility between the host and the biomaterial, is very important for the reliability of a biomaterial. It is a must for a newly produced biomaterial to meet the biocompatibility criteria, which are bound to certain rules by international organizations. One of the criteria of biocompatibility is genotoxicity. In this study, it was aimed to evaluate the genotoxicity of a commercial polyaxial pedicle screw in vitro. For this purpose, in vitro micronucleus test and bacterial reverse mutation test were performed. Extraction method was used for both tests. When the obtained results were compared statistically, it was concluded that the tested biomaterial was not genotoxic.

Source: International Journal of Veterinary and Animal Research (IJVAR)

DOI: 10.5281/zenodo.14583386

Authors: Özkabadayı, Yasin, Çerçi, Nebahat Aytuna

Language: English

Topic: Carcinogens and Genotoxicity Assessment

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

Funder: Kırıkkale Üniversitesi

OpenAlex ID: W6968302250

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