Acromegaly: a Severe Neuroendocrine Disorder With Multisystem Manifestations
Year: 2025
Type: article
Abstract: Acromegaly is a severe neuroendocrine disorder caused by chronic hypersecretion of growth hormone (GH), leading to pathological periosteal bone growth, cartilage proliferation, soft tissue hypertrophy, and internal organ enlargement. It also affects the cardiovascular, pulmonary, and endocrine systems, leading to metabolic disturbances. The disease primarily manifests between the ages of 20 and 40, though it can occur after the age of 50. Epidemiological studies estimate a prevalence of 125–295 cases per million adults and an annual incidence of 3–4 new cases per million. However, true prevalence is likely higher. This review discusses the pathophysiology, clinical manifestations, complications, and diagnostic challenges of acromegaly, emphasizing the importance of early recognition and intervention.
Author: Ergasheva Gulshan Tokhirovna
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W6968337029
FWCI:
Cites:
Cited by:
Related to: