Year: 2024
Type: article
Abstract: Background: Psychedelic drugs, such as psilocybin and MDMA, have re-emerged as promising therapeutic agents for psychiatric disorders. Current treatments for conditions like depression, anxiety, and PTSD are often associated with limited efficacy and significant side effects, necessitating innovative approaches. Psychedelics have shown potential to address these limitations by producing rapid and sustained improvements in mental health outcomes. Aim: This study aimed to evaluate the therapeutic efficacy of psychedelic drugs in reducing psychiatric symptoms and to assess their safety profile in a controlled clinical setting. Methods: A prospective observational study was conducted at NMCH, Patna, over one year, involving 100 participants with psychiatric disorders such as depression, anxiety, and PTSD. Participants underwent supervised psychedelic-assisted therapy sessions. Psychiatric symptoms were measured using standardized scales before and after the intervention. Statistical analyses were performed using SPSS version 23.0 to evaluate the significance of changes in scores. Results: The mean baseline psychiatric score was 27.2 (SD = 2.4), which significantly decreased to 17.2 (SD = 2.3) post-intervention, indicating an average improvement of 10 points (p < 0.001). Seventy percent of participants experienced a substantial improvement (≥10 points), with consistent effects across genders. Adverse effects were mild and transient, reported in less than 5% of participants. Conclusion: Psychedelic drugs demonstrated significant and sustained therapeutic benefits for psychiatric disorders, with minimal side effects. The findings suggest that psychedelics may serve as an effective alternative to conventional therapies, particularly for treatment-resistant cases. Recommendations: Further research is recommended to establish long-term safety, refine dosing protocols, and explore the use of psychedelics in larger and more diverse populations. Policymakers should consider revising regulations to facilitate broader clinical research and application.
Authors: Vinay Kumar, Priyanka Sharma, Amardeep Kumar, Nitya Nand Singh, Rinky Thakur
Language: English
Subfield: Clinical Psychology
Field: Psychology
Domain: Social Sciences
Open Access status: green
OpenAlex ID: W6968388488
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