A Review On: Antibacterial And Antifungal Activity Of 1,2,3-Triazoles And 1,2,4-Triazole Derivatives
Year: 2024
Type: article
Abstract: 1,2,3-Triazoles: Triazoles are renowned scaffolds that are simple to conjugate with additional heterocyclic groups. These compounds exhibit a variety of pharmacological effects, including antibacterial and anticancer activities. Researchers have targeted these triazole-conjugated structural motifs as common pharmacological targets. Additionally, a study synthesized and evaluated the antibacterial properties of 1,2,3-triazole derivatives. Some of these compounds demonstrated good antibacterial activity, making them potential candidates for further investigation. 1,2,4-Triazoles: Compounds containing the 1,2,4-triazole ring in their structure are characterized by multidirectional biological activity. Extensive research has proven significant antibacterial activity of this heterocyclic core. Rational design and development of novel antibacterial agents incorporating 1,2,4-triazole can help address microbial resistance. Molecular docking studies also suggested their potential as inhibitors for the novel SARS-CoV-2 virus. In summary, both 1,2,3-triazoles and 1,2,4-triazoles hold promise as antimicrobial agents, and further research in this area is essential for combating drug-resistant infections
Author: Abhiman S. Jadhav*, Vinayak S. Marulkar, V. Y. Lokhande, Rupesh R. Shinde, Pratik S. Dharmasale
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W6968425356