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Paravalvular Leak After Transcatheter Aortic Valve Implantation (TAVI): Comparative Outcomes of Percutaneous Closure Techniques Versus Conservative Management – A Systematic Review

Year: 2025

Type: article

Abstract: Background: Paravalvular leak (PVL) remains a significant complication following transcatheter aortic valve implantation (TAVI), associated with increased morbidity and mortality. The optimal management strategy—percutaneous closure versus conservative medical therapy—remains debated. Objectives: This study aims to compare the clinical outcomes, hemodynamic efficacy, and long-term survival rates between percutaneous device closure and conservative management in patients with post-TAVI PVL. Methods: A systematic review and meta-analysis were conducted, including randomized controlled trials (RCTs), cohort studies, and case series from major databases (PubMed, Embase, Cochrane Library). Primary endpoints included procedural success, all-cause mortality, heart failure rehospitalization, and echocardiographic parameters of regurgitation severity. Results: Percutaneous closure demonstrated superior reduction in PVL severity (OR 2.45, 95% CI 1.78–3.38, p < 0.001) and improved NYHA functional class compared to conservative management. However, procedural complications (e.g., device embolization, vascular injury) were non-negligible. Conservative therapy showed lower early morbidity but higher long-term heart failure recurrence. Conclusions: Percutaneous closure techniques offer significant hemodynamic benefits in eligible patients, while conservative management may be reserved for high-risk cases. Individualized patient assessment is crucial in determining the optimal therapeutic approach.

Source: Zenodo (CERN European Organization for Nuclear Research)

DOI: 10.5281/zenodo.15285940

Authors: Araceli Martínez Cervantes, Meyboll Edily Rodriguez Medina, Elsa Itzel Calderón Tapia, Carlos Emmanuel Guzman Solorzano, Jesus Miguel Valencia Correa

Institution: Institute for Social Security and Services for State Workers

Language: English

Topic: Cardiac Valve Diseases and Treatments

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W6968439687

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