Serum Anti-mullerian Hormone Levels Are Associated With Early Miscarriage in the Ivf/icsi Fresh Cycle
Year: 2025
Type: article
Abstract: Background: Anti-Müllerian hormone (AMH) is used as a marker of ovarian reserve in assisted reproductive technology. Its role in predicting early miscarriage in fresh in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) cycles is uncertain. In this study we aim to systematically review the association between serum AMH levels and early miscarriage in fresh IVF/ICSI cycles. Methods: A systematic review was conducted in accordance to PRISMA 2020 guidelines. Searches were performed in PubMed, Scopus, Web of Science, and Embase for studies published between 2005 and 2025. First-trimester miscarriage is the outcome reported by eligible studies. Seventeen studies met the inclusion criteria. Results: Most studies indicated association between elevated AMH levels and increased risk of early miscarriage, mainly in women with polycystic ovary syndrome (PCOS). Women with AMH ≥10.65 ng/mL experienced miscarriage rates up to twice as high as those with lower levels. Low AMH was linked to diminished ovarian response and suboptimal outcomes. A minority of studies reported no correlation. Conclusion: Elevated serum AMH levels are associated with an increased risk of early miscarriage in fresh IVF/ICSI cycles mainly in PCOS patients. AMH should be interpreted clinically to improve individualized fertility care.
Authors: IBTESAM FAWAZ ALSHAMMARI, MUHAMMAD AHMAD ABDULLAH ASIRI, AMAL SAAD SAEED ASEERI, GOFRAN MOHAMMED AL BRAHEEM, TAHANI MAHMOOD THABIT, Consultant Obstetrics & Gynecology, King Saud Medical City -Riyadh-KSA., SAAD KHALEEL ALONZE
Institutions: King Saud Medical City, King Saud University, Ministry of Health
Language: English
Subfield: Reproductive Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W6968466746
FWCI:
Cites:
Cited by:
Related to: