Myopathies
Year: 2025
Type: article
Abstract: The presence of endomysial inflammation unites the diverse group of acquired myopathies known as inflammatory myopathies. These conditions can currently be divided into five distinctive subsets based on gradually changing clinical, histological, and immunopathological characteristics as well as some autoantibody associations: Inclusion-Body-Myositis (IBM), Necrotizing Autoimmune Myositis (NAM), Dermatomyositis (DM), Polymyositis (PM), and Anti-synthetase syndrome-overlap myositis (Anti-SS-OM). It is necessary to accurately identify each subtype of inflammatory myopathy from the start in order to prevent disease mimics and go forward with early therapy initiation because each fraction has a unique immunopathogenesis, prognosis, and response to immunotherapies. The review outlines the key clinicopathologic features of each subset, emphasizing the value of integrating knowledge of immunopathology, muscle morphology, and clinical neurological evaluation to prevent incorrect diagnosis and treatment plans. The primary autoimmune indicators associated with autoreactive T cells, B cells, autoantibodies, and cytokines are discussed, together with the accompanying myodegenerative characteristics observed in IBM muscles. Most significantly, the
Authors: TOICHIEVA AIPERI ABDIMALIKOVNA, Nagarajan Aswini, Madheswaran maheshwari Aruna, Ashok Kumar Muthu bharath rajesh, Vijayan shewag
Institution: Osh State University
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W6968512744
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