Hemophagocytic Subtype of Intravascular Large B-cell Lymphoma: An Unusual Finding
Year: 2025
Type: article
Abstract: Intravascular lymphoma (IVL) is an aggressive and rare disease with a poor prognosis classified by the World Health Organization (WHO) as a subtype of diffuse large B-cell lymphoma (DLBCL). It is characterized by a proliferation of large neoplastic B cells within the lumina of small blood vessels, with minimal or no infiltration of the surrounding extravascular tissue. The hemophagocytic subtype typically occurs in adults, with a median age of around 70 years and with no sex predilection. Herein, we present a case with hemophagocytic syndrome, including splenomegaly, fever, cytopenia (anemia and thrombocytopenia), macrophage activation syndrome and lymphocytosis observed on peripheral blood smear, which developed for seven weeks in a 75-year-old lady. Histological study and immunohistochemical staining of the bone marrow biopsy revealed a proliferation of atypical lymphomatous cells within the lumen of small blood vessels.
Author: Hanae Ben Abdenbi1,2*, Abderrahim El Ktaibi1,2
Language: English
Subfield: Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W6969080752
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