Design, synthesis, and biological evaluation of bergapten derivatives as potent anti-pancreatic cancer agents
Year: 2025
Type: article
Abstract: Bergapten, a natural product from Zanthoxylum bungeanum Maxim., exhibits anticancer, antibacterial, anti-inflammatory, and hypolipidemic effects. A derivative, FSG-Y5 showed potent activity against pancreatic cancer cells PANC-1 (IC50 = 2.31 ± 0.25 µM) and CFPAC-1 (IC50 = 4.41 ± 0.47 µM), inhibiting their survival, migration, and invasion while inducing apoptosis via Bax and Cleaved caspase-3 regulation. FSG-Y5 also suppressed pancreatic cancer organoids and zebrafish tumor growth in a concentration and time-dependent manner. These findings highlight bergapten derivatives as promising anticancer candidates, with FSG-Y5 as a potential anti-pancreatic cancer agent for further study.
Source: Figshare
Authors: Yue, Ying, Liu, Jia-Rong, Wang, Nan, Wang, Xing-Rong, Ma, Jun-Yi, Yang, Jun-Li
Language: English
Topic: Bioactive natural compounds
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W6977080643
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