Year: 2025
Type: preprint
Abstract: Total-body dual X-ray absorptiometry (TBDXA) imaging is a relatively low-cost whole-body imaging modality, widely used for body composition assessment. We develop and validate a deep learning method for automatic fiducial point placement on TBDXA scans using 1,683 manually-annotated TBDXA scans. The method achieves 99.5% percentage correct keypoints in an external testing dataset. To demonstrate the value for shape and appearance modeling (SAM), our method is used to place keypoints on 35,928 scans for five different TBDXA imaging modes, then associations with health markers are tested in two cohorts not used for SAM model generation using two-sample Kolmogorov-Smirnov tests. SAM feature distributions associated with health biomarkers are shown to corroborate existing evidence and generate new hypotheses on body composition and shape's relationship to various frailty, metabolic, inflammation, and cardiometabolic health markers. Evaluation scripts, model weights, automatic point file generation code, and triangulation files are available at https://github.com/hawaii-ai/dxa-pointplacement.
Source: arXiv (Cornell University)
Authors: Bunnell, Arianna, Cataldi, Devon, Glaser, Yannik, Wolfgruber, Thomas K., Heymsfield, Steven, Zonderman, Alan B., Kelly, Thomas L., Sadowski, Peter, Shepherd, John A.
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W6979254709
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