Work

Resting State Functional Connectivity Patterns Associate with Alcohol Use Disorder Characteristics: Insights from the Triple Network Model

Year: 2025

Type: preprint

Abstract: Prolonged alcohol use results in neuroadaptations that mark more severe and treatment-resistant alcohol use. The goal of this study was to identify functional connectivity brain patterns underlying Alcohol Use Disorder (AUD)-related characteristics in fifty-five adults (31 female) who endorsed heavy alcohol use. We hypothesized that resting-state functional connectivity (rsFC) of the Salience (SN), Frontoparietal (FPN), and Default Mode (DMN) networks would reflect self-reported recent and lifetime alcohol use, laboratory-based alcohol seeking, urgency, and sociodemographic characteristics related to AUD. To test our hypothesis, we combined the triple network model (TNM) of psychopathology with a multivariate data-driven approach, regularized partial least squares (rPLS), to unfold concurrent functional connectivity (FC) patterns and their association with AUD-related characteristics. We observed three concurrent associations of interest: i) drinking and age-related cross communication between the SN and both the FPN and DMN; ii) family history density of AUD and urgency anticorrelations between the SN and FPN; and iii) alcohol seeking and sex-associated SN and DMN interactions. These findings provide an integrative interpretation for many individual findings reported in the literature relating functional connectivity signatures and AUD factors. Moreover, we identified a set of neural mechanisms and brain regions concomitant with AUD-related characteristics that can serve as potential treatment targets across clinical and preclinical models.

Source: arXiv (Cornell University)

Authors: Guerrero, Daniel, Dzemidzic, Mario, Moghaddam, Mahdi, Liu, Mintao, Avena-Koenigsberger, Andrea, Harezlak, Jaroslaw, Kareken, David A., Plawecki, Martin H., Cyders, Melissa A., Goñi, Joaquín

Institutions: Purdue University West Lafayette, Indiana University Indianapolis, Indiana University School of Medicine, Indiana Alcohol Research Center, Indiana University Bloomington, Indiana University

Language: English

Topic: Functional Brain Connectivity Studies

Subfield: Cognitive Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Eli Lilly and Company, Lilly Endowment, National Institutes of Health, National Institute of Neurological Disorders and Stroke, National Center for Advancing Translational Sciences

Awards: G9000210922, Indiana Clinical and Translational Sciences Institute

OpenAlex ID: W6979350214

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