Work

Degradation of human α- and β-defensins by culture supernatants of Porphyromonas gingivalis

Year: 2010

Type: dissertation

Abstract: Porphyromonas gingivalis produces proteases capable of degrading cytokines, host heme proteins, and some antimicrobial peptides. In this work, I show that P. gingivalis culture supernatants fully or partially degrade human neutrophil peptide alpha-defensins and human beta-defensins after 30 minutes. This observation suggests that proteases from P. gingivalis degrade defensins and this activity could abrogate defensin-related innate immune functions.

DOI: 10.17077/etd.dbmqnenp

Author: Matthew David Carlisle

Language: English

Topic: Antimicrobial Peptides and Activities

Subfield: Microbiology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W4507422

Cites: 112

Cited by:

Related to: 10