Year: 2001
Type: article
Abstract: Fumonisins are mycotoxins produced by certain Fusarium moulds, principally Fusarium moniliforme a worldwide corn contaminant.It is already well known that fumonisins are associated with various animal toxicosis and carcinomas, including leukoencephalomalacia (ELEM), porcine pulmonary oedema (PPE), hepatotoxicosis, hepatocarcinomas, nephrotoxicosis and immunosuppressive effects.Among fumonisin isomers FB 1 is a predominant molecular form and major toxicant.It has been found that FB 1 disrupts the sphingolipid metabolism on many types of cells and tissues through the inhibition of ceramide synthase, a key enzyme in de novo sphingolipid biosynthesis and reacylation of free sphingosine.The second mechanism of toxicity involves changes in polyunsaturated fatty acid and disruption of membrane phospholipids.Different toxic effects of FB 1 were evaluated in many kinds of animal, such as Equidae, swine, rat, mice rabbit, chicken, non-human primates and others.Exposure assessment, legislative and efficient detoxification is needed to be done in order to avoid unwanted consequences and economic losses.
Authors: Maja Šegvić, Stjepan Pepeljnjak
Language: English
Subfield: Plant Science
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W6981921892