Joint associations of accelerometer-measured physical activity and sedentary time with all-cause mortality: a harmonised meta-analysis in more than 44 000 middle-aged and older individuals
Year: 2020
Type: review
Study design: Systematic Review
Abstract: OBJECTIVES: To examine the joint associations of accelerometer-measured physical activity and sedentary time with all-cause mortality. METHODS: We conducted a harmonised meta-analysis including nine prospective cohort studies from four countries. 44 370 men and women were followed for 4.0 to 14.5 years during which 3451 participants died (7.8% mortality rate). Associations between different combinations of moderate-to-vigorous intensity physical activity (MVPA) and sedentary time were analysed at study level using Cox proportional hazards regression analysis and summarised using random effects meta-analysis. RESULTS: Across cohorts, the average time spent sedentary ranged from 8.5 hours/day to 10.5 hours/day and 8 min/day to 35 min/day for MVPA. Compared with the referent group (highest physical activity/lowest sedentary time), the risk of death increased with lower levels of MVPA and greater amounts of sedentary time. Among those in the highest third of MVPA, the risk of death was not statistically different from the referent for those in the middle (16%; 95% CI 0.87% to 1.54%) and highest (40%; 95% CI 0.87% to 2.26%) thirds of sedentary time. Those in the lowest third of MVPA had a greater risk of death in all combinations with sedentary time; 65% (95% CI 1.25% to 2.19%), 65% (95% CI 1.24% to 2.21%) and 263% (95% CI 1.93% to 3.57%), respectively. CONCLUSION: Higher sedentary time is associated with higher mortality in less active individuals when measured by accelerometry. About 30-40 min of MVPA per day attenuate the association between sedentary time and risk of death, which is lower than previous estimates from self-reported data.
Authors: Ulf Ekelund, Jakob Tarp, Morten W Fagerland, Jostein Steene Johannessen, Bjørge H Hansen, Barbara J Jefferis, Peter H Whincup, Keith M Diaz, Steven Hooker, Virginia J Howard, Ariel Chernofsky, Martin G Larson, Nicole Spartano, Ramachandran S Vasan, Ing-Mari Dohrn, Maria Hagströmer, Charlotte Edwardson, Thomas Yates, Eric J Shiroma, Paddy Dempsey, Katrien Wijndaele, Sigmund A Anderssen, I-Min Lee
Institutions: Norwegian Institute of Public Health, Norwegian School of Sport Sciences, University of Agder, University College London, University of London, St George's, University of London, Population Health Research Institute, Columbia University Irving Medical Center, San Diego State University, University of Alabama at Birmingham, Boston University, Karolinska Institutet, University of Leicester, University Hospitals of Leicester NHS Trust, NIHR Leicester Biomedical Research Centre, National Institutes of Health, National Institute on Aging, Baker Heart and Diabetes Institute, University of Cambridge, Medical Research Council, Brigham and Women's Hospital, Harvard University
Language: English
Topic: Physical Activity and Health
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Funders: American Heart Association, Coca-Cola Foundation, Cancer Research UK, National Institute for Health and Care Research, British Heart Foundation, European Commission, Stockholms Läns Landsting, Centrum för idrottsforskning, Norges Forskningsråd, Norges Idrettshøgskole, National Institutes of Health, Medical Research Council, National Health and Medical Research Council, National Institute on Aging, National Heart, Lung, and Blood Institute, National Cancer Institute, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Neurological Disorders and Stroke
Awards: G1075599542, Women's Health Study: Continued Follow-Up, Impact of Physical Activity on Stroke and Cognitive Function in Older Adults, G139823147, VCID and Stroke in a Bi-racial National Cohort, G1528515809, G1664136512, G2140171847, G2258234602, G229684361, G250621538, G2892497062, G299057155, British Regional Heart Study (BRHS): a long-term prospective investigation of cardiovascular disease (causes, pathways, prediction and prevention) among older British men (renewal), G3207630219, Cardiometabolic Outcomes in Multi-ethnic Physical Activity & Sedentary Behavior Study (COMPASS), G370598735, G376663933, G3879675704, G430560375, G4389161098, G4409035895, Physical Activity, Cardiometabolic Risk, and Target-Organ Damage in Older Adults, The EPIC-Norfolk prospective population study: biological and behavioural determinants of health and disease in an ageing population, Moving More and Sitting Less: Evidence to Inform the Prevention and Management of Type 2 Diabetes, G515689015, G5164707915, G5303647658, G5315906942, The Women's Health Study: Addition of New Data to Maximize its Research Impact, G5878857982, The Women's Health Study: Infrastructure Support for Continued Cohort Follow-up, G5897142711, NIHR Senior Investigator Award, G6192747883, G6206044308, G6641991021, Objectively Measured Physical Activity and Mortality in Women, THE FRAMINGHAM HEART STUDY-N01HC25195-268025195-268025195, TRIAL OF ASPIRIN AND VITAMIN E IN WOMEN, Understanding the associations between physical activity and sedentary behaviours with cardiovascular risk in older age: a population-based study with objective physical activity monitoring, G7249558043, Metabolic Profiling of Exercise to Predict Cardiometabolic Risk, G7630010743, Women's Health Study: Continued Follow-up, Women's Health Study: Infrastructure support for cohort follow-up, Physical activity epidemiology, G9000058182, G9000124674, G9000191827, G9000312666, UAB Diabetes Research Center, Proteomic Profiling of Precise Exercise Pathophenotypes Across the HFpEF Spectrum
OpenAlex ID: W3108517679