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Metabolic syndrome in inpatients with schizophrenia and major depressive disorder: case studies in the Casa de Saúde do Bom Jesus

Year: 2017
Type: dissertation
Study design: Observational Study
Abstract: Introduction: Metabolic syndrome (MetS) is a disorder with high prevalence in patients with mental illness. This is of importance since it can lead to increased morbidity and mortality due to metabolic causes and cardiovascular disease. More so, it associates with the prognosis of mental illness by reducing adherence to therapy and increasing functional limitation. Objective: To determine the prevalence of MetS in female inpatients with Schizophrenia and Major depressive disorder in the Casa de Saúde do Bom Jesus, between September 2016 and March 2017. Materials and methods: The work was a case study, with a consecutive sampling approach. A final sample of 80 (n= 40 SZ; n=40 MDD). Main inclusion criteria included being female over 18+ years old with a diagnosis of SZ or MDD, according to the international statistical classification of diseases (ICD-10), with treatment with antipsychotic or/and antidepressive drugs. The study parameters included anthropometric measures, blood pressure and biochemical variables [fasting glucose, high density lipoprotein (HDL), cholesterol and triglycerides]. Results: The overall mean age was of 51.5 years (SD=13.3; range 24-75 years). MetS was found in 46% of the inpatients considered; 38% in MDD patients and 55% in SZ patients. Of the components of the MetS, increased waist circumference was the most prevalent (73% for MDD and 85% for SZ), followed by low HDL< 50 mg/dl (65% in both groups). When considering for the number of Mets components, 94% of patients had at least one (1) criterion, with 35% of MDD having two (2) criteria and 25% of the SZ patients having three (3). MetS was associated with increased age and lower adherence of Mediterranean diet in MDD patients, and with higher body mass index in SZ patients. In SZ patients’ antipsychotic was associated with increased waist circumference. Conclusions: Patients with mental illness have a high prevalence of MetS independently of the diagnosis. Current findings may emphasize the critical need of care, with precise and detailed longitudinal monitoring. As such, it is important to monitor patients in any clinical setting regarding metabolic issues.
Language: English
Field: Medicine
Open Access status: green
OpenAlex ID: W6983452298
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