Work

Mitochondrial ribosomal proteins as aging regulators

Year: 2013

Type: article

Abstract: The present invention relates to methods of increasing lifespan, delaying aging, and/or preventing or treating an age-related disease or a mitochondrialdisease in a subject, comprising inducing a nuclear-mitochondrial OXPHOS protein dyssynchrony, including inhibiting the mitochondrial translation machinery function, as well as methods forscreening agents that are able to increase lifespan, inhibit or delay aging, and/or prevent or treat an age-related disease or disorder, or a mitochondrial disease or disorder, in a subject.

Source: Infoscience (Ecole Polytechnique Fédérale de Lausanne)

Authors: Auwerx, Johan, Houtkooper, Richardus, Mouchiroud, Laurent

Language: English

Topic: Mitochondrial Function and Pathology

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W6983453996

FWCI:

Cites:

Cited by:

Related to: 10