Requirement of Autophagy Proteins Beclin-1 and Map1-LC3b in the Induction of Innate and Adaptive Immune Responses to Respiratory Syncytial Virus Infection [electronic resource].
Year: 2014
Type: article
Abstract: secretion, and altered T cell cytokine production. Becn1+/- and LC3b-/- DCs were impaired in antiviral cytokine production, and elicited Th2- or Th17- skewed responses from co-cultured CD4+ T cells, respectively. Furthermore, studies using bone-marrow chimeric mice revealed a critical role for LC3b in restricting ER stress-dependent, inflammasome-mediated production of IL-1β by infected airway epithelial cells. Finally, neutralization of IL-17 or IL-1 receptor signaling in vivo ameliorated the development of lung pathology in LC3b-/- mice. Overall, these studies shed light on the importance of autophagy to the induction of antiviral immune responses and control of inflammation during RSV infection, and establish the autophagy pathway as a potential target for future therapeutic interventions.
Author: Reed, Michelle.
Language: English
Subfield: Cell Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W6986901610