Work

Stereotatic Heaw-charged-particle Bragg Peak Radiosurgery for the Treatment of Intracranial Arteriovenous Malformations in Childhood and Adolescence

Year: 1988

Type: article

Abstract: Forty patients aged 6 to 18 y have now been treated for inoperable intracranial arteriovenous malformations ( AVMs) using stereotactic heavy-charged-particle.Bragg peak radiosurgery at the Lawrence Berkeley Laboratory 184-inch Synchrocyclotron at the University of California Berkeley.This paper describes the procedures for selection of patients, the treatment protocol, and the neurologic and neuroradiologic responses to stereotactic radiosurgery in this age group.The AVM volumes treated ranged from 265 mm 3 to 60,000 mm 3 .The results are favorable; 20 of 25 patients have thus far had ~ 50% obliteration of the AVM within 1 y after treatment and 14 of 18 patients have thus far had total obliteration of the AVM by 2 y after treatment.Two patients hemorrhaged from a radiosurgically-treated AVM within 12 mo following treatment, but none thereafter.Complications include vasagenic edema and arterial occlusion; three patients have had neurologic worsening as definite or possible sequelae of treatment.The strengths and limitations of the method are discussed.

Source: eScholarship (California Digital Library)

Authors: Levy, R.F., Fabrikant, J.I., Frankel, K.A.

Institutions: University of California, Berkeley, Lawrence Berkeley National Laboratory

Language: English

Topic: Vascular Malformations Diagnosis and Treatment

Subfield: Clinical Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: U.S. Department of Energy

Awards: G1398330795, G1643223109, G193590374