Year: 2015
Type: article
Abstract: The alteration of cell physiological state is related to changes in intracellular calcium concentration. Calcium is a key regulator of mitochondrial function and acts at several levels within organelle to stimulate ATP synthesis. Mitochondrial Ca2+uptake was shown to control intracellular Ca2+signaling, cell metabolism, cell survival and other cell-type specific functions by buffering cytosolic Ca2+levels and regulating mitochondrial effectors. Mitochondrial matrix Ca2+overload can lead to enhanced generation of reactive oxygen species, triggering of the permeability transition pore, and cytochrome crelease, leading to apoptosis. There is the delicate balance between the positive and negative effects of Ca 2+and the signaling events that perturb this balance.
Authors: Головач, Н.Г., Чещевик, В.Т., Струмило, С.А., Анисько, П.Е., Лапшина, Е.А., Заводник, И.Б.
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W6988160392