Year: 2018
Type: article
Study design: Observational Study
Abstract: The human microbiota constitutes the vast number of microbes that inhabit our bodies and play key roles in a range of physiological processes, including metabolism, immune system education, and the establishment of health versus disease.The balance of bacterial species that inhabit the oral cavity play critical roles in maintaining dental health, and in the establishment and pathogenesis of dental diseases, including caries and periodontitis.Understanding the factors that contribute to the acquisition and establishment of the oral microbiota will provide insight into the management and treatment of dental diseases.The purpose of this study was to determine the contribution of genetics to oral bacterial transmission from mothers to their children by comparing biologic and adoptive motherchild dyads.Saliva, supragingival plaque and subgingival plaque was collected from forty-six biologic and fifty adoptive mother-child dyads for this study.16S rRNA gene amplicon sequencing was used for species level comparisons between groups.Community complexity as measured by Shannon Diversity was found to be higher in biologic children's supragingival and subgingival plaque samples when compared to adoptive children and mothers.No significant differences were noted in Bray Curtis dissimilarities of species abundance or Jaccard distances of species presence between mothers and their children when comparing biologic and adoptive dyads.It is likely that differences were not observed between dyads because our analysis was at the species iii level, and healthy individuals share a core oral microbiome.Future analyses will be performed at the strain level, where the influence of genetics is more likely to be evident.
Author: Steinkamp, Heidi Marie
Institution: The Ohio State University
Language: English
Subfield: Periodontics
Field: Dentistry
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W6990063973