Development and Application of Novel Methods to Study Tumor Heterogeneity and Cancer Genome Evolution [electronic resource].
Year: 2014
Type: article
Abstract: to detect short tandem repeat (STR) variation using paired-end short-read next-generation DNA sequencing data. Unlike previous methods which are limited to finding short STR alleles, my method is capable of finding both STR alleles shorter than a read and those longer than the read or the read pair. This capability addresses the need to reliably detect expanded STR alleles in germline DNA that underlie many rare inherited diseases as well as somatic aberrations characterized by microsatellite instability.
Author: Li, Bo.
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W6990410851