The effects of fluoxetine on hippocampal antioxidative defense in depressive-like rats
Year: 2016
Type: conference-paper
Abstract: Exposure of an organism to chronic social isolation (CSIS) causes modulation of antioxidant defense system in the brain which has been shown to have important role in depression. Fluoxetine (Flx) is the first-line treatment for depression; however, precise mechanism of its action still remains elusive. The aim of this study was to investigate the effect of 3 weeks of Flx treatment on malondialdehyde (MDA) level, an oxidative stress parameter as well as on the activities of GSH-dependent antioxidative enzymes in the hippocampus of rats exposed to 6 weeks of CSIS. Increased MDA content following CSIS and Flx treatment (controls or CSIS) of rats, suggests on hippocampal oxidative damage. CSIS induced reduction of hippocampal glutathione-S-transferase that was reversed by Flx treatment, as well as an increase in glutathione peroxidase/reductase activities. The present study contributes to our understanding of the mechanisms that underlie the antidepressant activity of Flx in rats exposed to CSIS, an animal model of depression.
Authors: Perić, Ivana, Todorović, Nevena, Stanisavljević, Andrijana, Đorđević, Neda O., Filipović, Dragana
Language: English
Subfield: Pharmacology (medical)
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W6990614802