Year: 2019
Type: article
Abstract: Background: The transcription factor CREB (cAMP response element-binding protein) has been shown to be activated by drugs of abuse in reward-related brain regions.However, the effects of natural reward on CREB activation are under-investigated.Here we investigated the effects of social interaction conditioned place preference (CPP) on CREB phosphorylation at two different time points (early 1 hour and late 24 hours after the CPP test) in various brain regions involved in reward and stress-reactions of 1) rats that express social interaction CPP or 2) control saline rats that received saline in both compartments of the CPP apparatus.Finding: We found that social interaction CPP did not alter CREB activation 1 hour after the CPP test but decreased CREB phosphorylation 24 hours after the CPP test, specifically in the basolateral amygdala.Conclusion: As stress increases CREB activation in several brain regions including the basolateral amygdala, these results confirm our previous finding that social interaction reward may have anti-stress effects.
Author: Rana El Rawas
Institution: Innsbruck Medical University
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: diamond
Funder: Austrian Science Fund
OpenAlex ID: W2968333143