Year: 2015
Type: article
Abstract: 月 日現在 ２７６ １１ 円 36,200,000研究成果の概要(英文)：Different pluripotent stem cell lines have characteristic differences making each of them unique, which is important in regenerative medicine.We compared the biological and molecular profile of 4 human embryonic stem (ES) cell lines, two human induced pluripotent stem (iPS) cell lines and two control cell types at four stages between undifferentiated to differentiated states, to identify individual characteristics.In the undifferentiated state, a group of genes were identified which differentiate ES cell lines from others.In the differentiated state, however, these gene clusters were not maintained and the individuality of each cell line became prominent, as disclosed by exhaustive gene expression analysis.The individual characteristics of each cell line were portrayed three-dimensionally on a globe.These developments are useful for analyzing the individual characteristics of pluripotent stem cell lines prior to their application in regenerative medicine.
Source: SOAR (Shinshu University)
Author: 佐々木, 克典
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W6992903069