Year: 2008
Type: conference-paper
Abstract: Bone metabolism is performed by bone-degrading osteoclasts and bone-building osteoblasts on bone surface. The osteocyte is a third cell type in bone that is derived from osteoblast lineage cells and embedded in the mineralized matrix. In order to delineate the in vivo function of the osteocyte, we have developed a transgenic mouse model that enables targeted ablation of osteocytes following a single injection of diphtheria toxin. Under normal loading condition, ablation of osteocytes caused aberrant activation of osteoclastic bone resorption with elevated expression of RANKL (Receptor Activator of NF-KB Ligand). In contrast, during unloading by tail suspension, the osteocyte-depleted mice were protected from disuse-induced bone atrophy. These data suggest that osteocytes play a pivotal role in sensing and/or transducing mechanical signals to adapt the structure and function of bone according to changing mechanical environments.
Authors: 池田, 恭治, 辰巳, 佐和子, 石井, 清朗, 小林, 利寛, 竹下, 淳, 網塚, 憲生, Li, Minqi, 河野, 憲二, 伊東, 昌子, Ikeda, Kyoji, Tatsumi, Sawako, Ishii, Kiyoaki, Kobayashi, Toshihiro, Takeshita, Sunao, Amizuka, Norio, Li, Minqi, Kono, Kenji, Ito, Masako
Language: English
Topic: Bone Metabolism and Diseases
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W6995217121