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Clinical inquiries. Which medications can be split without compromising efficacy and safety?

Year: 2006

Type: article

Abstract: Split tablets of lisinopril are as effective as whole tablets of the same dose for hypertension (strength of recommendation [SOR]: B, based on small randomized crossover study). Similarly, split tablets of atorvastatin, lovastatin, and simvastatin are no less effective for lowering cholesterol (SOR: B, based on retrospective cohort studies). Extended-release, enteric-coated, or tablets that cannot be split accurately are not appropriate for splitting (SOR: C, based on observational studies); the accuracy of splitting also depends on device used and user skill (SOR: C, based on observational study).

Source: PubMed

Authors: John Noviasky, Vincent Lo, Diane D Luft, Joseph Saseen

Institution: St. Elizabeth Healthcare

Language: English

Topic: Pharmacy and Medical Practices

Subfield: Pharmacy

Field: Health Professions

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2530928758

FWCI: 3.843

Cites:

Cited by: 23

Related to: 10