Alagebrium chloride, a novel AGE cross linkage breaker, inhibits neointimal proliferation after carotid balloon injury in diabetic animal model
Year: 2008
Type: dissertation
Abstract: Recent report has shown that longstanding hyperglycemia in diabetes leads to generation of AGEs (advanced glycation end products) and their accumulation induce vessel wall memory and vascular perturbation that lead to progression of atherosclerosis, plaque instability.Moreover, AGEs are reported to have a role in neointimal formation in animal experiment of arterial stenosis.AGE mediated cross link formation of proteins such as collagen will not only result in stiffening of the arteries, but will result in
Author: 김진배
Language: English
Subfield: Clinical Biochemistry
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W3083486003