Antibody Responses to Severe Acute Respiratory Syndrome Coronavirus 2 in the Serum and Cerebrospinal Fluid of Patients With Coronavirus Disease 2019 and Neurological Symptoms
Year: 2021
Type: article
Study design: Observational Study
Abstract: Antibody responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in serum and cerebrospinal fluid (CSF) samples from 16 patients with coronavirus disease 2019 and neurological symptoms were assessed using 2 independent methods. Immunoglobulin G (IgG) specific for the virus spike protein was found in 81% of patients in serum and in 56% in CSF. SARS-CoV-2 IgG in CSF was observed in 2 patients with negative serological findings. Levels of IgG in both serum and CSF were associated with disease severity (P < .05). All patients with elevated markers of central nervous system damage in CSF also had CSF antibodies (P = .002), and CSF antibodies had the highest predictive value for neuronal damage markers of all tested clinical variables.
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,052
Awards: G1943697781, G292763017, G3809224024, G4960203590, G5111822078, G6069138294, Acute kidney injury - mechanisms and novel therapeutic targets in large animal models, Genetic basis for antibody diversity, Pathways to Alzheimer's disease, G712881263, G7198253607, Towards Pandemic Preparedness: Assessing the reassortment dynamics of influenza A viruses, Acute kidney injury - mechanisms and novel therapeutic targets in large animal models, What determines amyloid beta aggregation and toxicity in Alzheimer’s disease?
OpenAlex ID: W3136767774