The Distributions of Duffy Antigens and Phenotypes Among Blood Donors in King Abdulaziz Medical City-Western Region, Saudi Arabia: A Cross-Sectional Study
Year: 2025
Type: article
Abstract: Amr J Halawani,1 Sahal A Jamalallail,2 Abdullah M Algarni,2 Mohammad H Alsomali,2 Sulaiman S Alabsi,2 Ammar M Sahl,2 Afnan T Kumosani,2 Saja M Asali,2 Alaa H Qudayr,2 Banan A Mallah,2 Ahmed A Mari,2 Hiam O Mulla,3– 5 Ali H Alhussain Snr,6 Sarah M Alahwal,2 Faisal D Alomari2 1Department of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Saudi Arabia; 2King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Jeddah, Saudi Arabia; 3College of Applied Medical Sciences, King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia; 4King Abdullah International Medical Research Center, Jeddah, Saudi Arabia; 5Ministry of National Guard Health Affairs, Jeddah, Saudi Arabia; 6King Abdulaziz Medical City, Ministry of National Guard Health Affairs, AlAhsa, Saudi ArabiaCorrespondence: Amr J Halawani, Department of Clinical Laboratory Sciences Faculty of Applied Medical Sciences Umm Al-Qura University, Makkah, Saudi Arabia, Email [email protected]: The Duffy (FY) is considered one of the clinically significant blood group systems. Anti-Fya and anti-Fyb can cause hemolytic transfusion reactions and hemolytic disease of the fetus and newborn. This study investigated the prevalence of FY antigens and phenotypes in Saudi Arabian and non-Saudi Arabian blood donors.Methods: A total of 25611 blood donors were enrolled in this study from January 2020 to May 2024, at the blood bank center of King Abdulaziz Medical City-Western Region (KAMC-WR), Jeddah, Saudi Arabia. Serotyping was conducted to identify Fya and Fyb antigens as well as the four FY phenotypes using a solid phase technique.Results: The majority of the blood donors were Saudi Arabians (n = 21,496, 83.93%), while the remaining donors were non-Saudis (n = 4115, 16.07%). The frequencies of Fya and Fyb among the Saudi Arabian donors were 28.20% and 28.41%, respectively. Conversely, the distributions of the Fya and Fyb antigens among the non-Saudi Arabian donors occurred at 44.88% and 39.83%, respectively. The Fy(a−b−) phenotype was the most common FY phenotypes among the Saudi Arabian and non-Saudi Arabian and were 50.07% and 33.80%, respectively. The incidences of the FY phenotypes were statistically significantly different in Saudis compared to non-Saudis (p < 0.01).Conclusion: The prevalence of the FY antigens and phenotypes is reported among blood donors. The Fy(a−b−) phenotype was the most widespread among Saudis and non-Saudis. It is crucial to include the FY antigens in the transfusion screening panel especially for both blood donors as well as patients especially the transfusion-dependent patients.Keywords: Duffy blood group, Duffy-null, blood donors, immunohematology, Saudi Arabia
Authors: Halawani AJ, Jamalallail SA, Algarni AM, Alsomali MH, Alabsi SS, Sahl AM, Kumosani AT, Asali SM, Qudayr AH, Mallah BA, Mari AA, Mulla HO, Alhussain Snr AH, Alahwal SM, Alomari FD
Language: English
Topic: Blood groups and transfusion
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W6999956319
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