Year: 2006
Type: dissertation
Abstract: In this thesis we focused on the causes \nand consequences of hepatic steatosis. Epidemiological studies in \nhumans, as well as experimental studies in animal models, have shown an \nassociation between visceral obesity and dyslipidemia, insulin \nresistance and type 2 diabetes mellitus. The mechanism underlying this \nassociation remains unclear. Recently, attention has focused on the role\n of excessive accumulation of triglycerides (TG) in the liver (hepatic \nsteatosis) in this association. Hepatic steatosis was considered a \nbenign condition until it was discovered that a nonalcoholic fatty liver\n is associated with many cardiovascular risk factors. Subsequently, many\n studies have shown a strong association between hepatic TG content and \nhepatic insulin resistance. The studies in this thesis show that \nhepatic steatosis is actively and passively involved in the metabolic \ndisturbances in the glucose and lipid metabolism. The prevalence of \nhepatic steatosis in western countries is high and will certainly \nincrease with the epidemics of obesity and diabetes. This will put an \nincreasing number of subjects at risk for disturbances in the glucose \nand lipid metabolism and concomitantly for cardiovascular disease.
Author: Boer, A.M. den
Language: English
Subfield: Hepatology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Award: G8624189410
OpenAlex ID: W7000751769