Work

Histological validation of the brain cell body imaging with diffusion MRI at ultrahigh field

Year: 2019

Type: article

Abstract: Biophysical modelling of diffusion-weighted MRI (DW-MRI) data can help to gain more insight into brain microstructure. However, models need to be validated. This work validates a recently-developed technique for non-invasive mapping of brain cell-body (soma) size/ density with DW-MRI, by using ultrahigh-field DW-MRI experiments and histology of mouse brain. Predictions from numerical simulations are experimentally confirmed and brain’s maps of MR-measured soma size/density are shown to correspond very well with histology. We provide differential contrasts between cell layers that are less expressed in tensor analyses, leading to novel complementary contrasts of the brain tissue. Limitations and future research directions are discussed.

Source: ORCA Online Research @Cardiff (Cardiff University)

Authors: Palombo, M, Nunes, D, Alexander, D, Zhang, H, Shemesh, N

Language: English

Topic: Advanced Neuroimaging Techniques and Applications

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

Open Access status: green

Funders: European Commission, Engineering and Physical Sciences Research Council

Awards: Anatomy-Driven Brain Connectivity Mapping, DTP - University College London, G3018663809, Medical image computing for next-generation healthcare technology, G5264968607, G7974379690, G8662128564

OpenAlex ID: W7001001953

FWCI: 0.57

Cites: 2

Cited by: 4

Related to: 10