Involvement of the Endosomal-lysosomal System in the Processing of Disease-associated Tau in Alzheimer’s Disease and Corticobasal Degeneration
Year: 2021
Type: dissertation
Abstract: The microtubule-associated protein tau pathologically aggregates in multiple neurodegenerative diseases. In neurons, tau matures from pre-aggregates into neurofibrillary tangles (NFTs) in Alzheimer’s disease (AD). In corticobasal degeneration (CBD) only dot-like intracytoplasmic aggregates of tau are seen. The endosomal-lysosomal system (ELS) has been examined in relation to Amyloid-beta processing in AD, however, there is a paucity of data on the role of the ELS in the processing of tau. Therefore, we performed a neuron-specific double-immunolabeling morphometric study to evaluate the lysosomal enzyme cathepsin D and its relation to different cellular deposits of disease-associated tau (AT8) in AD and CBD. The area density of cathepsin D immunoreactivity levels showed significant decrease in all types of tau aggregates in AD but not in CBD. AT8 and cathepsin D colocalized significantly more in CBD compared to AD. Our results indicate a differential response of the ELS to tau accumulation in AD and CBD.
Source: TSpace (University of Toronto)
Author: Jafrani, Areeb Rashid
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W7001202568