Work

Investigating the MAPT haplotype as a risk factor for neurodegenerative diseases with induced pluripotent stem cells

Year: 2022

Type: dissertation

Abstract: This study contributes to the elucidation of the MAPT haplotype-related risk for neurodegenerative diseases. iPS cell lines with different MAPT genotypes were differentiated into neurons and compared systematically. Significant differences in the expression profiles of the disease-relevant proteins TAU and α-SYNUCLEIN between the H1/H1 and the H2/H2 haplotype groups have been identified. The described cell model, therefore, offers a helpful resource for future modeling of sporadic tauopathies.

Source: mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich)

Authors: Strauß, Tabea, Höglinger, Günter 1971-, Technische Universität München

Language: English

Topic: Alzheimer's disease research and treatments

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7001383432

Cites: 194

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Related to: 10