Year: 2023
Type: dissertation
Abstract: Soluble amyloid beta oligomers (AβOs) consist of aggregated Aβ monomers and impair cognition by causing early neuronal hyperactivity in Alzheimer’s disease (AD). However, the group of AβOs is manifold and less is known about the hyperactivity-inducing potential of specific Aβ molecules. In hippocampal brain slices, I found that Aβ monomers are initially nontoxic to neurons in contrast to Aβ dimers but acquire neurotoxicity through oligomerization to larger Aβ aggregates. Therefore, blocking Aβ monomer aggregation is an auspicious therapeutic target against AD.
Authors: Knauer, Manuel Marco, Konnerth, Arthur 1953-, Technische Universität München
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W7002014828