Work

Structural Biology of Bacterial Type IV Secretion Systems

Year: 2015

Type: review

Abstract: Type IV secretion systems (T4SSs) are large multisubunit translocons, found in both gram-negative and gram-positive bacteria and in some archaea. These systems transport a diverse array of substrates from DNA and protein-DNA complexes to proteins, and play fundamental roles in both bacterial pathogenesis and bacterial adaptation to the cellular milieu in which bacteria live. This review describes the various biochemical and structural advances made toward understanding the biogenesis, architecture, and function of T4SSs.

Source: Annual Review of Biochemistry

DOI: 10.1146/annurev-biochem-062911-102821

Authors: Vidya Chandran Darbari, Gabriel Waksman

Institutions: Imperial College London, Institute of Structural and Molecular Biology, University College London, Birkbeck, University of London

Language: English

Topic: Bacterial Genetics and Biotechnology

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

Funder: Wellcome Trust

Award: An integrated study of a bacterial secretion nanomachine.