Cell-cell interaction in a synthetic co-culture: PHA production from sunlight and CO2 co-cultivating Synechococcus elongatus and Pseudomonas putida
Year: 2023
Type: dissertation
Abstract: In labs, microbes are often grown alone for simplicity. Yet, in nature, they thrive in complex communities. This thesis investigates a synthetic co-culture of Synechococcus elongatus PCC 7942 cscB feeding Pseudomonas putida derivatives with sucrose. The results present a highly controllable co-cultivation process that doubled the polyhydroxyalkanoate (PHA) titer compared to previous studies. Further, the co-partners showed multi-level interactions, including transcriptional, proteomic, and metabolic changes, as well as highly increased cyanomaberium growth.
Authors: Kratzl, Franziska Pia, Kremling, Andreas 1965-, Technische Universität München
Language: English
Subfield: Biomaterials
Field: Materials Science
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W7008659583