Des aphasies primaires progressives logopéniques à la maladie d’Alzheimer : le diagnostic acoustique précoce, une alternative à la ponction lombaire ?
Year: 2022
Type: dissertation
Study design: Observational Study
Abstract: Logopenic primary progressive aphasia (lvPPA), a syndromic disorder centered on language impairment, still presents unpredictable evolutions to neurodegenerative pathologies as Alzheimer disease (AD). Actual language assessment tests and lumbar puncture, focused on AD diagnosis, cannot precisely distinguish the symptoms, or predict their progression at onset time. We analyzed acoustic markers aiming to discriminate lvPPA and AD and the influence of AD biomarkers on the acoustic profiles at the beginning of the disease. We recruited people with AD (n = 8) and with lvPPA (n = 8) with a Cerebrospinal fluid biomarkers profile determined by lumbar puncture. The participants performed a sentence repetition task that allow assessing potential lvPPA phonological loop deficits. We found that temporal and prosodic markers significantly differentiate lvPPA and AD group at an early stage of the disease. Biomarkers and acoustic profiles comparisons discriminated two lvPPA subgroups according to their biomarkers. lvPPA with AD biomarkers presents an acoustic profile equivalent to an atypical AD form with a specific alteration of phonological loop. Although, lvPPA without AD biomarkers has an acoustic profile approximating with the frontotemporal dementia one. Therefore, these results allow us to classify lvPPA differentially from AD based on acoustic markers on a sentence repetition task. Furthermore, acoustic analysis can be considered as a clinically efficient alternative to lumbar puncture. It offers the possibility to facilitate early, specific, and accessible neurodegenerative diagnosis and may ease early care with speech therapy, preventing the progression of symptoms.
Source: HAL
Author: da Cunha, Eloïse
Institution: Université Côte d'Azur
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7009042992