Die Rolle von CDC42 in der zellulären Dynamik: Auswirkungen auf Stress, Alterung und Hämatopoese
Year: 2024
Type: dissertation
Abstract: CDC42 plays a critical role in maintaining hematopoietic niche homeostasis, particularly under stress conditions like 5FU treatment and stem cell transplantation. Overactivation of CDC42 disrupts F-actin fiber orientation, mitochondrial function, and autophagy/mitophagy in mesenchymal stem and progenitor cells, leading to bone marrow (BM) failure, increased senescence, and reduced bone volume. Therefore, pharmacological attenuation of CDC42 can act as a potential therapeutic target for diseases associated with BM failure, hematopoietic dysfunction and osteoporosis.
Authors: Landspersky, Theresa, Oostendorp, Robert A. J. 1963-, Technische Universität München
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7009205762