Gene therapy of radiation fibrosis using adenovirus expressing decoy wnt receptor (sLRP6E1E2)
Year: 2016
Type: dissertation
Abstract: 1 I. INTRODUCTION •••••••••••••••••••••••••••••••••••••••••••••••••••••••••••• 3 II.MATERIALS AND METHODS••••••••••••••••••••••••••••••••••••••••••• 5 of 15Gy was delivered to the dorsal skin of each mouse.Thirty mice were randomized into three groups: PBS, control adenovirus (dE1-k35) and decoy wnt receptor-expressing adenovirus (dE1-k35/sLRP6E1E2).The mice were observed for 16 weeks, and there was no significantly different gross change observed in comparison with controls.In semi-quantitative analysis with Masson's trichrome staining, excessive collagen deposition was suppressed by sLRP6E1E2-expressing adenovirus treatment.These results support that modulation of wnt/β-catenin pathway has the potential to decrease the severity of radiation-induced dermal fibrosis. ------------------------------------------------
Author: 이동원
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7009973701