Year: 2016
Type: book-chapter
Abstract: Throughout evolution, organisms have adapted a set of dedicated proteins for iron–sulfur cluster biogenesis. Among the identified iron–sulfur cluster assembly proteins in Escherichia coli, IscA has a unique and strong iron-binding activity, and the iron-bound IscA can readily provide iron for iron–sulfur cluster assembly in proteins in vitro under aerobic conditions. IscA also has a high binding affinity for copper, and excess copper competes for the iron-binding sites in IscA and effectively blocks the IscA-mediated iron–sulfur cluster biogenesis. It is thus postulated that IscA may act as an iron chaperone to recruit intracellular iron and deliver iron for iron–sulfur cluster biogenesis under aerobic conditions.
Source: Wiley eBooks
Author: Huangen Ding
Institution: Louisiana State University
Language: English
Subfield: Biochemistry
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2508762280