Is it feasible to directly access the bundle’s specific myelin content, instead of averaging? A study with Microstructure Informed Tractography
Year: 2019
Type: article
Abstract: Diffusion MRI connectometry is a widely used tool to investigate features of structural connectomes that reflect differences in white matter tracks integrity. It consists in averaging microstructural tissues properties (obtained from any voxel-wise map) along streamlines recovered with diffusion tractography. Nevertheless, the average of a microstructural measure is a weak information about an entire bundle. Using microstructure-informed tractography (COMMIT), we were able to simultaneously estimate fiber’s specific myelin water fraction, intra-axonal volume fraction, and g-ratio. We also computed new connectomes with bundles’ specific measures instead of the commonly used averages.
Authors: Schiavi, Simona, Pizzolato, Marco, Ocampo-Pineda, Mario, Canales-Rodriguez, Erick Jorge, Thiran, Jean-Philippe, Daducci, Alessandro
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7010858055