Year: 2015
Type: preprint
Study design: Observational Study
Abstract: It is commonly thought that human genetic diversity in non-African populations was shaped primarily by an out-of-Africa dispersal 50-100 thousand yr ago (kya). Here, we present a study of 456 geographically diverse high-coverage Y chromosome sequences, including 299 newly reported samples. Applying ancient DNA calibration, we date the Y-chromosomal most recent common ancestor (MRCA) in Africa at 254 (95% CI 192-307) kya and detect a cluster of major non-African founder haplogroups in a narrow time interval at 47-52 kya, consistent with a rapid initial colonization model of Eurasia and Oceania after the out-of-Africa bottleneck. In contrast to demographic reconstructions based on mtDNA, we infer a second strong bottleneck in Y-chromosome lineages dating to the last 10 ky. We hypothesize that this bottleneck is caused by cultural changes affecting variance of reproductive success among males.
Source: Genome Research
Authors: Monika Karmin, Lauri Saag, Mário Vicente, Melissa A. Wilson Sayres, Mari Järve, Ulvi Gerst Talas, Siiri Rootsi, Anne-Mai Ilumäe, Reedik Mägi, Mario Mitt, Luca Pagani, Tarmo Puurand, Zuzana Faltyskova, Florian Clemente, Alexia Cardona, Ene Metspalu, Hovhannes Sahakyan, Bayazit Yunusbayev, Georgi Hudjashov, Michael DeGiorgio, Eva-Liis Loogväli, Christina Eichstaedt, Mikk Eelmets, Gyaneshwer Chaubey, Kristiina Tambets, Sergei Litvinov, Maru Mormina, Yali Xue, Qasim Ayub, Grigor Zoraqi, Thorfinn Sand Korneliussen, Farida Akhatova, Joseph Lachance, Sarah Tishkoff, Kuvat Momynaliev, François-Xavier Ricaut, Pradiptajati Kusuma, Harilanto Razafindrazaka, Denis Pierron, Murray P. Cox, Gazi Nurun Nahar Sultana, Rane Willerslev, Craig Muller, Michael Westaway, David Lambert, Vedrana Skaro, Lejla Kovačevic´, Shahlo Turdikulova, Dilbar Dalimova, Rita Khusainova, Natalya Trofimova, Vita Akhmetova, Irina Khidiyatova, Daria V. Lichman, Jainagul Isakova, Elvira Pocheshkhova, Zhaxylyk Sabitov, Nikolay A. Barashkov, Pagbajabyn Nymadawa, Evelin Mihailov, Joseph Wee Tien Seng, Irina Evseeva, Andrea Bamberg Migliano, Syafiq Abdullah, George Andriadze, Dragan Primorac, Lubov Atramentova, Olga Utevska, Levon Yepiskoposyan, Damir Marjanovic´, Alena Kushniarevich, Doron M. Behar, Christian Gilissen, Lisenka Vissers, Joris A. Veltman, Elena Balanovska, Miroslava Derenko, Boris Malyarchuk, Andres Metspalu, Sardana Fedorova, Anders Eriksson, Andrea Manica, Fernando L. Mendez, Tatiana M. Karafet, Krishna R. Veeramah, Neil Bradman, Michael F. Hammer, Ludmila P. Osipova, Oleg Balanovsky, Elza K. Khusnutdinova, Knut Johnsen, Maido Remm, Mark G. Thomas, Chris Tyler-Smith, Peter A. Underhill, Eske Willerslev, Rasmus Nielsen, Mait Metspalu, Richard Villems, Toomas Kivisild
Institutions: Estonian Biocentre, University of Tartu, University of Cambridge, University of California, Berkeley, Institute of Molecular Biology, National Academy of Sciences of Armenia, Russian Academy of Sciences, Institute of Biochemistry and Genetics of Ufa Scientific Centre, University of Auckland, Pennsylvania State University, University of Winchester, Wellcome Sanger Institute, University of Medicine Tirana, University of Tirana, University of Copenhagen, Bashkir State University, Kazan Federal University, Georgia Institute of Technology, University of Pennsylvania, Centre National de la Recherche Scientifique, Université Toulouse III - Paul Sabatier, AMIS - Laboratoire d'anthropologie moléculaire et imagerie de synthèse, Université de Toulouse, Eijkman Institute for Molecular Biology, Massey University, University of Dhaka, Aarhus University, Griffith University, Genos (Croatia), University of Osijek, Centogene (Germany), Academy of Sciences Republic of Uzbekistan, Institute of Cytology and Genetics, National Academy of Sciences of the Republic of Kyrgyzstan, Kuban State Medical University, L. N. Gumilyov Eurasian National University, Nazarbayev University, North-Eastern Federal University, National Cancer Centre Singapore, Anthony Nolan, Northern State Medical University, University College London, Raja Isteri Pengiran Anak Saleha Hospital, University of Split, V. N. Karazin Kharkiv National University, International Burch University, National Academy of Sciences of Belarus, Institute of Genetics and Cytology of the National Academy of Sciences of Belarus, Radboud University Medical Center, Research Centre for Medical Genetics, Institute of Biological Problems of the North, King Abdullah University of Science and Technology, Stanford Medicine, Stanford University, University of Arizona, Stony Brook University, Vavilov Institute of General Genetics, University Hospital of North Norway, Estonian Academy of Sciences
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: bronze
Funders: Wellcome Trust, Leverhulme Trust, European Commission, Agence Nationale de la Recherche, Eesti Teadusfondi, Russian Foundation for Basic Research, Eesti Teadusagentuur, Haridus- ja Teadusministeerium, Lundbeckfonden, Russian Science Foundation, Tartu Ülikool, Kazan Federal University, Biotechnology and Biological Sciences Research Council, Russian Academy of Sciences, Center of Translational Genomics, University of Tartu, European Regional Development Fund, National Institute of General Medical Sciences, FP7 Ideas: European Research Council, FP7 People: Marie-Curie Actions
Awards: G1390638048, G150168930, G1758707715, G218565478, G2236735545, New Zealand Estonian French Research Exchange Scheme, Integrative Genomics of Body Size and Metabolism in Ethnically Diverse Africans, G3587719953, G3588481721, G3866460319, G4113798697, Unexplored human history in the Indian Ocean: Human biological adaptations to the Indian Ocean slave trade and Indonesian dispersal to Madagascar, Detecting signatures of natural selection in the human genome with geographically explicit models, The dawn of whole genomic era in archaeogenetics, G4968681203, G5479191210, Human genetic diversity in South Asia, genesis and implications, G6765915823, G6876618760, G7007108502, An inter-disciplinary approach for identifying evolutionary active regions in the human genome, Computational studies of genome sequences, G7659589011, Novel diagnostic markers of nervous system diseases and factors predicting treatment outcome, Wellcome Trust Sanger Institute - generic account for deposition of all core- funded research papers, G8943806891
OpenAlex ID: W7014680338