Work

Ruthenium-catalyzed transfer hydrogenation of alkynes

Year: 2025

Type: article

Abstract: A complete reduction of alkynes using a combination of [RuCl$_2$(p-cymene)]$_2$, DTBM-SEGPHOS, and a paraformaldehyde/water system as the hydrogen source was developed, affording alkanes in 52–99% yields. In addition, the preparation of alkenes from terminal alkynes and aryl iodides by a tandem process of Pd/Cu-catalyzed Sonogashira reaction followed by Ru-catalyzed transfer hydrogenation is reported, affording alkenes in 38–99% yields. This multicatalysis proceeds via three consecutive reactions and can be extended further, as shown by adding an iodine-catalyzed cis–trans alkene isomerization step.

Source: Repository of the University of Ljubljana (University of Ljubljana)

Authors: Jankovič, Dominik, Košmrlj, Janez, Gazvoda, Martin

Language: English

Topic: Asymmetric Hydrogenation and Catalysis

Subfield: Inorganic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

OpenAlex ID: W7015031600

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