Year: 2023
Type: dissertation
Abstract: In placental mammals, a subset of genes is expressed in a mono-allelic and parent-dependent manner. This hereditary phenomenon, regulated through DNA methylation, is called parental genomic imprinting. While less studied in pigs compared to humans or mice, it is nevertheless associated with important traits in the swine industry. This manuscript provides a synthesis of (i) the use of biological information for the improvement of commercial pig populations and (ii) the knowledge acquired on parental imprinting and its influence on phenotype. Additionally, it reports an experimental study characterizing the H19/IGF2-KCNQ1/CDKN1C region in pigs, which is involved in growth and muscular development. An original multi-omics approach demonstrates that this region harbors molecular signatures of parental imprinting and provides valuable data for a more refined understanding of the involved regulatory mechanisms
Source: HAL
Author: Jacomet, Eva
Language: English
Subfield: Genetics
Domain: Life Sciences
SDG: Zero hunger
Open Access status: green
OpenAlex ID: W7015341264