Alzheimr型痴呆の老人斑の嗜銀性はギ酸前処理により消失する
Year: 1989
Type: article
Abstract: We studied the effect of formic acid pretreatment on silver stains and βprotein immunostain on brain tissue samples from patients with the Alzheimer-type dementia (AID). The argyrophilia of the amyloid component of senile plaques (SP), which could be visualized by modified Bielschowsky and periodic acid-methenamine silver (PAM) stains, was not visible when the specimens were pretreated with formic acid. In contrast, the pretreatment highly enhanced the immunoreactivity of this component with βprotein antiserum. Our findings suggest that formic acid pretreatment selectively abolishes the argyrophilia of the amyloid component of SP.
Authors: Yamaguchi, Haruyasu, Hirai, Shunsaku, Nakazato, Yoichi
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W7017306289