A comparative review on the resolution of 3D bioprinting over 2D cell cultures in cancer models
Year: 2024
Type: article
Abstract: The tumor microenvironment, composed of non-neoplastic cells and the extracellular matrix, plays a pivotal role in cancer progression. Traditional two-dimensional (2D) cell cultures fail to capture its complexity, resulting in disparities in drug responses compared to three-dimensional (3D) models. Recent research highlights the precision of 3D bioprinted cancer models, revolutionizing cancer research. 3D bioprinting offers diverse applications, including personalized tumor models for individualized drug testing. These models replicate physiological conditions, providing accurate drug screening for efficacy and toxicity. It also facilitates the study of metastasis mechanisms and therapeutic target identification. Moreover, 3D bioprinting aids in optimizing cancer treatments, such as gene and immunotherapies, and allows precise drug delivery to cancer cells. It supports medical education with realistic training tools and offers an ethical alternative to animal testing, potentially reducing its necessity in cancer research. In essence, 3D bioprinting is advancing cancer research by providing highly accurate models that closely mimic the tumor microenvironment, enhancing personalized medicine, drug screening, therapeutic development, and education. The present review delves into the multifaceted applications of 3D bioprinting in cancer research while exploring future directions and innovations in 3D bioprinting for Cancer Models.
Authors: Palanisamy Sadasivam, Manju, Anthony, Josephine, Kumar, Ashok, Peramaiyan, Rajendran
Institution: Meenakshi Academy of Higher Education and Research
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W7017912053