The dysbiosis of the bacterial population of the digestive system (intestinal microbiota) in patients with metabolic syndrome improves after two models of healthy diets: a diet rich in complex carbohydrates and a Mediterranean diet. CORDIOPREV study
Year: 2017
Type: dissertation
Abstract: The microbial community harbored in the human intestine, commonly known as\n\t\t\t\t the gut microbiota, is considered an organ fully integrated in the host which plays an\n\t\t\t\t important role in metabolism, physiology, nutrition and the immune function. The gut\n\t\t\t\t microbiota has coevolved with us and the changes in its composition and/or structure\n\t\t\t\t can have major consequences for human health and disease. At present, it is known that\n\t\t\t\t microbial imbalance or dysbiosis of the gut microbiota is associated with metabolic\n\t\t\t\t disorders such as Metabolic Syndrome, Obesity, Type 2 Diabetes and Cardiovascular\n\t\t\t\t Disease. In fact, some studies have suggested that changes in the intestinal microbiota\n\t\t\t\t may trigger pathogenic mechanisms that promote inflammation, insulin resistance and\n\t\t\t\t the development of Metabolic Syndrome. In this context, the relationship between the\n\t\t\t\t composition of the intestinal microbiota and human health has led to the design of\n\t\t\t\t strategies to promote the prevalence of beneficial bacteria that improve health status.\n\t\t\t\t Recent evidence has shown that significant alterations in the intestinal microbiota have\n\t\t\t\t been associated with alterations in diet, mainly influenced by the consumption of dietary\n\t\t\t\t fiber from fruit and vegetables. Studies are therefore needed to research into the\n\t\t\t\t possibility that diet-induced alterations in the intestinal microbiota contribute to an\n\t\t\t\t improvement in intestinal disorders and related diseases. Our hypothesis is that the consumption of two healthy diets, Mediterranean diet\n\t\t\t\t and Low Fat diet, corrects the dysbiosis of the intestinal microbiota present in patients\n\t\t\t\t with Metabolic Syndrome, after a prolonged dietary intervention at least one year. On\n\t\t\t\t the other hand, the null hypothesis is that the long-term consumption of two healthy diets, Mediterranean diet and Low Fat diet, not corrects the dysbiosis of the intestinal\n\t\t\t\t microbiota present in patients with Metabolic Syndrome.
Author: Haro Mariscal, Carmen María
Language: English
Topic: Gut microbiota and health
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W7018369862