Defining the Relationship between Biomarkers of Oxidative and Inflammatory Stress and the Risk for Atherosclerosis in Astronauts during and after Long-Duration Spaceflight
Year: 2013
Type: article
Abstract: Background• It is not known if astronauts participating in long-duration space flight and exploration missions beyond low Earth orbit are at an elevated risk for cardiovascular diseases, in particular atherosclerosis.• Data from Earth/clinical studies suggest that the space flight environment has the potential to increase cardiovascular risks due to oxidative stress.• Reactive oxygen species (ROS, or free radicals) are produced naturally by the body and are present in environment, as are antioxidants.• Disrupting the balance between ROS and anti-oxidants increases risk of oxidative damage (cellular components, DNA) and inflammation.• Stress, radiation, and poor diet practices have been shown to disrupt this balance and may present during spaceflight.
Authors: Ploutz-Snyder, Robert, Westby, Christian M., Smith, Scott M., Lee, Stuart M. C., Stenger, Michael B., Platts, Steven H.
Language: English
Subfield: Physiology (medical)
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7018430290